Neurobiology of Disease Neurotoxic Activation of Microglia Is Promoted by a Nox1- Dependent NADPH Oxidase
نویسندگان
چکیده
Cyril Chéret,1,2 Annie Gervais,1,2 Aurélia Lelli,1,2 Catherine Colin,1,2 Lahouari Amar,2,3 Philippe Ravassard,2,3 Jacques Mallet,2,3 Ana Cumano,4 Karl-Heinz Krause,5 and Michel Mallat1,2 1Inserm, Unité Mixte de Recherche (UMR) 711, Institut Fédératif de Recherche 70, 75013 Paris, France, 2Université Pierre et Marie Curie Paris 06, 75005 Paris, France, 3Centre National de la Recherche Scientifique, UMR 7091, 75013 Paris, France, 4Inserm, U668, Institut Pasteur, 75724 Paris Cedex 15, France, and 5Biology of Ageing Laboratories, University of Geneva, 1211 Geneva, Switzerland
منابع مشابه
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase.
Reactive oxygen species (ROS) modulate intracellular signaling but are also responsible for neuronal damage in pathological states. Microglia, the resident CNS macrophages, are prominent sources of ROS through expression of the phagocyte oxidase which catalytic subunit Nox2 generates superoxide ion (O2(.-)). Here we show that microglia also express Nox1 and other components of nonphagocyte NADP...
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